• Gene id: 126298

Gene Summary

• Gene Symbol: IRGQ   Gene   UCSC   Ensembl
• Aliases: FKSG27, IRGQ1
• Gene name: immunity related GTPase Q
• Alternate names: immunity-related GTPase family Q protein, immunity-related GTPase family, Q, immunity-related GTPase family, Q1,
• Gene location: 19q13.31 (44712642: 44723830)     Exons: 5     NC_000003.12

Protein Summary

• Protein general information: Q8WZA9  
  • Name: Immunity related GTPase family Q protein
  • Length: 623  
  • Mass: 62717
• Sequence:

  MPPPQGDVTALFLGPPGLGKSALIAALCDKDVETLEAPEGRPDSGVPSLRAAGPGLFLGELSCPPAAPGPWAAEA
  NVLVLVLPGPEGNGEPLAPALGEAALAALARGTPLLAVRNLRPGDSQTAAQARDQTAALLNSAGLGAADLFVLPA
  NCGSSDGCEELERLRAALQSQAEALRRLLPPAQDGFEVLGAAELEAVREAFETGGLEAALSWVRSGLERLGSARL
  DLAVAGKADVGLVVDMLLGLDPGDPGAAPASVPTAPTPFPAPERPNVVLWTVPLGHTGTATTAAAASHPTHYDAL
  ILVTPGAPTEKDWAQVQALLLPDAPLVCVRTDGEGEDPECLGEGKMENPKGESLKNAGGGGLENALSKGREKCSA
  GSQKAGSGEGPGKAGSEGLQQVVGMKKSGGGDSERAAALSPEDETWEVLEEAPPPVFPLRPGGLPGLCEWLRRAL
  PPAQAGALLLALPPASPSAARTKAAALRAGAWRPALLASLAAAAAPLPGLGWACDVALLRGQLAEWRRGLGLEPT
  ALARRERALGLASGELAARAHFPGPVTRAEVEARLGAWAGEGTAGGAALGALSFLWPAGGAAATGGLGYRAAHGV
  LLQALDEMRADAEAVLAPPEPAQ

• Structural information:
  • Protein Domains: (223..44-)
    (/note="IRG-type-G")
  • Interpro: IPR030385  IPR040070  
  • Prosite: PS51716
  • STRING: ENSP00000387535
• Other Databases: GeneCards:  IRGQ  Malacards:  IRGQ

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005525	GTP binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq