• Gene id: 125113

Gene Summary

• Gene Symbol: KRT222   Gene   UCSC   Ensembl
• Aliases: KA21, KRT222P
• Gene name: keratin 222
• Alternate names: keratin-like protein KRT222, keratin 222, type II, keratin-222 pseudogene,
• Gene location: 17q21.2 (40665176: 40654664)     Exons: 8     NC_000017.11

Protein Summary

• Protein general information: Q8N1A0  
  • Name: Keratin like protein KRT222 (Keratin 222) (Keratin 222 pseudogene)
  • Length: 295  
  • Mass: 34158
• Sequence:

  MELSQLLNEIRANYEKILTRNQIETVLSTRIQLEEDISKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAV
  ERGLENSLHASEQHYQMQLQDLETVIEGLEKELQEVRRGIEKQLQEHEMLLNTKMRLEQEIATYRHLLEKEEIRY
  YGCIQGGKKDKKPTTSRVGFVLPSAIINEISFTTKVPQKYENENVETVTKQAILNGSIVKESTEAHGTIQTEKVD
  EVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLETKQDNLPDIEVRLIMRRSCSIPSIKPPSTAN

• Structural information:
  • Protein Domains: (1..15-)
    (/note="IF-rod)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01188"-)
  • Interpro: IPR018039  IPR039008  IPR002957  
  • Prosite: PS00226 PS51842
  • STRING: ENSP00000377616
• Other Databases: GeneCards:  KRT222  Malacards:  KRT222

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005198	structural molecule activity	IEA	molecular function
GO:0005882	intermediate filament	IEA	cellular component
GO:0005882	intermediate filament	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881