• Gene id: 123688

Gene Summary

• Gene Symbol: HYKK   Gene   UCSC   Ensembl
• Aliases: AGPHD1
• Gene name: hydroxylysine kinase
• Alternate names: hydroxylysine kinase, 5-hydroxy-L-lysine kinase, 5-hydroxylysine kinase, aminoglycoside phosphotransferase domain-containing protein 1,
• Gene location: 15q25.1 (78507563: 78537372)     Exons: 6     NC_000015.10
• OMIM: 614681

Protein Summary

• Protein general information: A2RU49  
  • Name: Hydroxylysine kinase (5 hydroxy L lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain containing protein 1)
  • Length: 373  
  • Mass: 41933
• Sequence:

  MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNP
  DLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKL
  AAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECINHG
  DLNDHNILIESSKSASGNAEYQVSGILDFGDMSYGYYVFEVAITIMYMMIESKSPIQVGGHVLAGFESITPLTAV
  EKGALFLLVCSRFCQSLVMAAYSCQLYPENKDYLMVTAKTGWKHLQQMFDMGQKAVEEIWFETAKSYESGISM

• Structural information:
  • Interpro: IPR002575  IPR011009  
  • STRING: ENSP00000455459
• Other Databases: GeneCards:  HYKK  Malacards:  HYKK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0019202	amino acid kinase activity	IBA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0047992	hydroxylysine kinase activity	IEA	molecular function
GO:0047992	hydroxylysine kinase activity	IDA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006554	lysine catabolic process	TAS	biological process
GO:0047992	hydroxylysine kinase activity	TAS	molecular function
GO:0005737	cytoplasm	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00310	Lysine degradation

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)