• Gene id: 123036

Gene Summary

• Gene Symbol: TC2N   Gene   UCSC   Ensembl
• Aliases: C14orf47, C2CD1, MTAC2D1, Tac2-N
• Gene name: tandem C2 domains, nuclear
• Alternate names: tandem C2 domains nuclear protein, C2 calcium-dependent domain containing 1, membrane targeting (tandem) C2 domain containing 1, tandem C2 protein in nucleus,
• Gene location: 14q32.12 (154272628: 154275874)     Exons: 7     NC_000001.11

Protein Summary

• Protein general information: Q8N9U0  
  • Name: Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain containing protein 1) (Tandem C2 protein in nucleus) (Tac2 N)
  • Length: 490  
  • Mass: 55284
• Sequence:

  MATEFIKSCCGGCFYGETEKHNFSVERDFKAAVPNSQNATISVPPLTSVSVKPQLGCTEDYLLSKLPSDGKEVPF
  VVPKFKLSYIQPRTQETPSHLEELEGSARASFGDRKVELSSSSQHGPSYDVYNPFYMYQHISPDLSRRFPPRSEV
  KRLYGSVCDLRTNKLPGSPGLSKSMFDLTNSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDFG
  RLNVKLFYNSSVEQIWITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVHFKSSAKEGSNAIEFMETFVFAIKLQ
  NLQTVRLVFKIQTQTPRKKTIGECSMSLRTLSTQEMDYSLDITPPSKISVCHAELELGTCFQAVNSRIQLQILEA
  RYLPSSSTPLTLSFFVKVGMFSSGELIYKKKTRLLKASNGRVKWGETMIFPLIQSEKEIVFLIKLYSRSSVRRKH
  FVGQIWISEDSNNIEAVNQWKETVINPEKVVIRWHKLNPS

• Structural information:
  • Protein Domains: (223..34-)
    (/note="C2-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00041-)
    (344..47-)
    (/note="C2-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00041"-)
  • Interpro: IPR000008  IPR035892  IPR037786  IPR037788  IPR030542  
  • Prosite: PS50004
  • CDD: cd08684 cd08692
  • STRING: ENSP00000387882
• Other Databases: GeneCards:  TC2N  Malacards:  TC2N

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005575	cellular_component	ND	cellular component
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881