• Gene id: 119587

Gene Summary

• Gene Symbol: CPXM2   Gene   UCSC   Ensembl
• Aliases: CPX2, UNQ676
• Gene name: carboxypeptidase X, M14 family member 2
• Alternate names: inactive carboxypeptidase-like protein X2, 4632435C11Rik, carboxypeptidase Hlo, carboxypeptidase X (M14 family), member 2, carboxypeptidase-like protein X2, cytosolic carboxypeptidase,
• Gene location: 10q26.13 (123944093: 123745635)     Exons: 21     NC_000010.11
• OMIM: 617348

Protein Summary

• Protein general information: Q8N436  
  • Name: Inactive carboxypeptidase like protein X2
  • Length: 756  
  • Mass: 85870
• Sequence:

  MSRPGTATPALALVLLAVTLAGVGAQGAALEDPDYYGQEIWSREPYYARPEPELETFSPPLPAGPGEEWERRPQE
  PRPPKRATKPKKAPKREKSAPEPPPPGKHSNKKVMRTKSSEKAANDDHSVRVAREDVRESCPPLGLETLKITDFQ
  LHASTVKRYGLGAHRGRLNIQAGINENDFYDGAWCAGRNDLQQWIEVDARRLTRFTGVITQGRNSLWLSDWVTSY
  KVMVSNDSHTWVTVKNGSGDMIFEGNSEKEIPVLNELPVPMVARYIRINPQSWFDNGSICMRMEILGCPLPDPNN
  YYHRRNEMTTTDDLDFKHHNYKEMRQLMKVVNEMCPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYI
  AGAHGNEVLGRELLLLLVQFVCQEYLARNARIVHLVEETRIHVLPSLNPDGYEKAYEGGSELGGWSLGRWTHDGI
  DINNNFPDLNTLLWEAEDRQNVPRKVPNHYIAIPEWFLSENATVAAETRAVIAWMEKIPFVLGGNLQGGELVVAY
  PYDLVRSPWKTQEHTPTPDDHVFRWLAYSYASTHRLMTDARRRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYL
  HTNCFELSIYVGCDKYPHESQLPEEWENNRESLIVFMEQVHRGIKGLVRDSHGKGIPNAIISVEGINHDIRTAND
  GDYWRLLNPGEYVVTAKAEGFTASTKNCMVGYDMGATRCDFTLSKTNMARIREIMEKFGKQPVSLPARRLKLRGQ
  KRRQRG

• Structural information:
  • Protein Domains: (134..29-)
    C (/note="F5/8-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00081"-)
  • Interpro: IPR008969  IPR000421  IPR008979  IPR000834  
  • Prosite: PS00132 PS01285 PS01286 PS50022
  • CDD: cd00057
  • STRING: ENSP00000241305
• Other Databases: GeneCards:  CPXM2  Malacards:  CPXM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016485	protein processing	IBA	biological process
GO:0006518	peptide metabolic process	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0004181	metallocarboxypeptidase activity	IBA	molecular function
GO:0004181	metallocarboxypeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq