• Gene id: 118672

Gene Summary

• Gene Symbol: PSTK   Gene   UCSC   Ensembl
• Aliases: C10orf89
• Gene name: phosphoseryl-tRNA kinase
• Alternate names: L-seryl-tRNA(Sec) kinase, O-phosphoseryl-tRNA(Sec) kinase,
• Gene location: 10q26.13 (122980400: 122990389)     Exons: 8     NC_000010.11
• OMIM: 611310

Protein Summary

• Protein general information: Q8IV42  
  • Name: L seryl tRNA(Sec) kinase (EC 2.7.1.164) (O phosphoseryl tRNA(Sec) kinase)
  • Length: 348  
  • Mass: 39527
• Sequence:

  MKTAENIRGTGSDGPRKRGLCVLCGLPAAGKSTFARALAHRLQQEQGWAIGVVAYDDVMPDAFLAGARARPAPSQ
  WKLLRQELLKYLEYFLMAVINGCQMSVPPNRTEAMWEDFITCLKDQDLIFSAAFEAQSCYLLTKTAVSRPLFLVL
  DDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLQRNGQRPQALPPETIHLMGRKLEKPNPEKNAWEHNSLT
  IPSPACASEASLEVTDLLLTALENPVKYAEDNMEQKDTDRIICSTNILHKTDQTLRRIVSQTMKEAKGNQEAFSE
  MTFKQRWVRANHAAIWRIILGNEHIKCRSAKVGWLQCCRIEKRPLSTG

• Structural information:
  • Interpro: IPR013641  IPR020028  IPR027417  
  • STRING: ENSP00000357882
• Other Databases: GeneCards:  PSTK  Malacards:  PSTK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000049	tRNA binding	IBA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0043915	L-seryl-tRNA(Sec) kinase activity	IEA	molecular function
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa00970	Aminoacyl-tRNA biosynthesis
hsa00450	Selenocompound metabolism

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray