• Gene id: 115548

Gene Summary

• Gene Symbol: FCHO2   Gene   UCSC   Ensembl
• Gene name: FCH and mu domain containing endocytic adaptor 2
• Alternate names: F-BAR domain only protein 2, FCH domain only 2, FCH domain only protein 2,
• Gene location: 5q13.2 (72956040: 73090521)     Exons: 28     NC_000005.10
• OMIM: 0

Protein Summary

• Protein general information: Q0JRZ9  
  • Name: F BAR domain only protein 2
  • Length: 810  
  • Mass: 88924
• Sequence:

  MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFAPVWDV
  FKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQ
  ERLKKEGATQREIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIK
  EIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK
  DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLD
  ELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSAR
  PTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPT
  VGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN
  ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLAT
  YWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGS
  GSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLADC

• Structural information:
  • Protein Domains: (3..25-)
    (/note="F-BAR-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01077-)
    (542..80-)
    (/note="MHD-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00404"-)
  • Interpro: IPR027267  IPR031160  IPR001060  IPR030122  IPR028565   IPR018808  
  • Prosite: PS51741 PS51072
  • PDB: 2V0O
  • PDBsum: 2V0O
  • DIP: 29488
  • STRING: ENSP00000393776
• Other Databases: GeneCards:  FCHO2  Malacards:  FCHO2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008092	cytoskeletal protein binding	IBA	molecular function
GO:0005905	clathrin-coated pit	IBA	cellular component
GO:0072583	clathrin-dependent endocytosis	IBA	biological process
GO:0048488	synaptic vesicle endocytosis	IBA	biological process
GO:0048268	clathrin coat assembly	IBA	biological process
GO:0030136	clathrin-coated vesicle	IBA	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0005856	cytoskeleton	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005905	clathrin-coated pit	IDA	cellular component
GO:0030136	clathrin-coated vesicle	IDA	cellular component
GO:0072659	protein localization to plasma membrane	ISS	biological process
GO:0001786	phosphatidylserine binding	ISS	molecular function
GO:0072583	clathrin-dependent endocytosis	IMP	biological process
GO:0072583	clathrin-dependent endocytosis	IMP	biological process
GO:0048268	clathrin coat assembly	IMP	biological process
GO:0035091	phosphatidylinositol binding	ISS	molecular function
GO:0010324	membrane invagination	ISS	biological process
GO:0005886	plasma membrane	ISS	cellular component
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISS	molecular function
GO:0072583	clathrin-dependent endocytosis	IEA	biological process
GO:0005905	clathrin-coated pit	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005905	clathrin-coated pit	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0061024	membrane organization	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001786	phosphatidylserine binding	IEA	molecular function
GO:0005905	clathrin-coated pit	IEA	cellular component
GO:0072659	protein localization to plasma membrane	IEA	biological process
GO:0048488	synaptic vesicle endocytosis	IEA	biological process
GO:0098835	presynaptic endocytic zone membrane	IEA	cellular component
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0010324	membrane invagination	IEA	biological process
GO:0030136	clathrin-coated vesicle	IEA	cellular component
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0048488	synaptic vesicle endocytosis	IEA	biological process
GO:0005905	clathrin-coated pit	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)