• Gene id: 113177

Gene Summary

• Gene Symbol: IZUMO4   Gene   UCSC   Ensembl
• Aliases: C19orf36, IMAGE:4215339
• Gene name: IZUMO family member 4
• Alternate names: izumo sperm-egg fusion protein 4, putative SAMP14 binding protein variant 1, putative SAMP14 binding protein variant 2, sperm 22 kDa protein c113,
• Gene location: 19p13.3 (2096668: 2099589)     Exons: 8     NC_000019.10
• OMIM: 0

Protein Summary

• Protein general information: Q1ZYL8  
  • Name: Izumo sperm egg fusion protein 4 (Sperm 22 kDa protein c113)
  • Length: 232  
  • Mass: 26510
  • Tissue specificity: Detected in sperm. {ECO
• Sequence:

  MALLLCLVCLTAALAHGCLHCHSNFSKKFSFYRHHVNFKSWWVGDIPVSGALLTDWSDDTMKELHLAIPAKITRE
  KLDQVATAVYQMMDQLYQGKMYFPGYFPNELRNIFREQVHLIQNAIIESRIDCQHRCGIFQYETISCNNCTDSHV
  ACFGYNCESSAQWKSAVQGLLNYINNWHKQDTSMRPRSSAFSWPGTHRATPAFLVSPALRCLEPPHLANLTLEDA
  AECLKQH

• Structural information:
  • Interpro: IPR029389  
  • STRING: ENSP00000378712
• Other Databases: GeneCards:  IZUMO4  Malacards:  IZUMO4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray