• Gene id: 11276

Gene Summary

• Gene Symbol: SYNRG   Gene   UCSC   Ensembl
• Aliases: AP1GBP1, SYNG
• Gene name: synergin gamma
• Alternate names: synergin gamma, AP1 gamma subunit binding protein 1, AP1 subunit gamma-binding protein 1, adaptor-related protein complex 1 gamma subunit-binding protein 1, gamma-synergin,
• Gene location: 17q12 (37609495: 37514806)     Exons: 26     NC_000017.11
• Gene summary(Entrez): This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connec
• OMIM: 607291

Protein Summary

• Protein general information: Q9UMZ2  
  • Name: Synergin gamma (AP1 subunit gamma binding protein 1) (Gamma synergin)
  • Length: 1314  
  • Mass: 140654
• Sequence:

  MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQG
  PIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKL
  RLLSSVKPKTGEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEV
  GHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVP
  DAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPD
  ALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQV
  VKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKS
  SENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGTDDGFTDFKTADSVSPLEPPTKDKTFPPSFPSGTI
  QQKQQTQVKNPLNLADLDMFSSVNCSSEKPLSFSAVFSTSKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSL
  FGEYSGLAPVGEQDDFADFMAFSNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTAASTKYDVFRQ
  LSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAVAFRHTKEDSASVKSLDLPSIGGSSVGK
  EDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADIEDLKYAAFGSYSSNFAVSTLTSYDWSDRD
  DATQGRKLSPFVLSAGSGSPSATSILQKKETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTS
  EQKEYENRDYKDFTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSEKPKISKFDFLVATSQSKMKS
  SEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLNEKPALPVIRDKYKDLTGEVEENE
  RYAYEWQRCLGSALNVIKKANDTLNGISSSSVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQ
  LLKDIDKVWNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEEKPAEEHPKKAFNS
  ETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPDLL

• Structural information:
  • Protein Domains: (295..38-)
    (/note="EH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00077"-)
  • Interpro: IPR011992  IPR000261  IPR039656  
  • Prosite: PS50031
  • CDD: cd00052
  • PDB: 2MX7
  • PDBsum: 2MX7
  • STRING: ENSP00000483453
• Other Databases: GeneCards:  SYNRG  Malacards:  SYNRG

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030130	clathrin coat of trans-Golgi network vesicle	IBA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0006886	intracellular protein transport	TAS	biological process
GO:0030121	AP-1 adaptor complex	TAS	cellular component
GO:0005794	Golgi apparatus	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881