• Gene id: 112479

Gene Summary

• Gene Symbol: ERI2   Gene   UCSC   Ensembl
• Aliases: EXOD1, ZGRF5
• Gene name: ERI1 exoribonuclease family member 2
• Alternate names: ERI1 exoribonuclease 2, enhanced RNAi three prime mRNA exonuclease homolog 2, exonuclease domain containing 1, exonuclease domain-containing protein 1, exoribonuclease 2, zinc finger, GRF-type containing 5,
• Gene location: 16p12.3 (20806471: 20780192)     Exons: 12     NC_000016.10

Protein Summary

• Protein general information: A8K979  
  • Name: ERI1 exoribonuclease 2 (EC 3.1. . ) (Exonuclease domain containing protein 1)
  • Length: 691  
  • Mass: 77401
• Sequence:

  MATKRLARQLGLIRRKSIAPANGNLGRSKSKQLFDYLIVIDFESTCWNDGKHHHSQEIIEFPAVLLNTSTGQIDS
  EFQAYVQPQEHPILSEFCMELTGIKQAQVDEGVPLKICLSQFCKWIHKIQQQKNIIFATGISEPSASEVKLCAFV
  TWSDWDLGVCLEYECKRKQLLKPVFLNSWIDLRATYKLFYRRKPKGLSGALQEVGIEFSGREHSGLDDSRNTALL
  AWKMIRDGCVMKITRSLNKVPTKKNFSILARNLNTIQVEEMSACNISIQGPSIYNKEPKNIINPHEKVQMKSICA
  NSPIKAQQDQLQVKNNIKASLHNVKSSLPLFNTKSSTSVGQLQSPTLNSPIYMQKQGKNEHLAFNTKSKASTVGS
  ELVLVSTTVPTVHHVSDLEMSSTLDCLPVLADWEDVVLLPASQPEENVDCTVPISDSDLEISFNSGERLMVLKEL
  EMSSHENFGDIEETPQKSETSKSIVYKSPHTTIYNVKEAKDPGSDISAFKLPEHKSSTFNRVNANMSHPLVLGKH
  PLLSGGTKRNPCSPQAFPPAKKQPFTIHEEKPTSSDCSPVRSSSWRRLPSILTSTVNLQEPWKSGKMTPPLCKCG
  RRSKRLVVSNNGPNHGKVFYCCPIGKYQENRKCCGYFKWEQTLQKERANSMVPSHSTGGLTFSSPETSHICDRNL
  SISTKNSLRLRPSMRN

• Structural information:
  • Protein Domains: (37..22-)
    (/note="Exonuclease"-)
  • Interpro: IPR013520  IPR012337  IPR036397  IPR010666  
  • STRING: ENSP00000350651
• Other Databases: GeneCards:  ERI2  Malacards:  ERI2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	IBA	molecular function
GO:0000175	3'-5'-exoribonuclease activity	IBA	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004527	exonuclease activity	IEA	molecular function
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0006259	DNA metabolic process	IEA	biological process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)