• Gene id: 11247

Gene Summary

• Gene Symbol: NXPH4   Gene   UCSC   Ensembl
• Aliases: NPH4
• Gene name: neurexophilin 4
• Alternate names: neurexophilin-4, alternative protein NXPH4,
• Gene location: 12q13.3 (57216793: 57226448)     Exons: 2     NC_000012.12
• OMIM: 609699

Protein Summary

• Protein general information: O95158  
  • Name: Neurexophilin 4
  • Length: 308  
  • Mass: 33065
  • Tissue specificity: Expressed in brain, spleen, and testis.
• Sequence:

  MRLLPEWFLLLFGPWLLRKAVSAQIPESGRPQYLGLRPAAAGAGAPGQQLPEPRSSDGLGVGRAWSWAWPTNHTG
  ALARAGAAGALPAQRTKRKPSIKAARAKKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNGTFSVYFRHNSSSLGNL
  SVSIVPPSKRVEFGGVWLPGPVPHPLQSTLALEGVLPGLGPPLGMAAAAAGPGLGGSLGGALAGPLGGALGVPGA
  KESRAFNCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPFKVICIFVSFLSFDYKLVQKVCPDYNF
  QSEHPYFG

• Structural information:
  • Interpro: IPR010450  IPR026845  
  • STRING: ENSP00000333593
• Other Databases: GeneCards:  NXPH4  Malacards:  NXPH4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005575	cellular_component	ND	cellular component
GO:0007218	neuropeptide signaling pathway	NAS	biological process
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray