• Gene id: 11179

Gene Summary

• Gene Symbol: ZNF277   Gene   UCSC   Ensembl
• Aliases: NRIF4, ZNF277P
• Gene name: zinc finger protein 277
• Alternate names: zinc finger protein 277, nuclear receptor-interacting factor 4, zinc finger protein (C2H2 type) 277, zinc finger protein 277 pseudogene,
• Gene location: 7q31.1 (112206611: 112343933)     Exons: 12     NC_000007.14
• OMIM: 605465

Protein Summary

• Protein general information: Q9NRM2  
  • Name: Zinc finger protein 277 (Nuclear receptor interacting factor 4)
  • Length: 450  
  • Mass: 52788
• Sequence:

  MAASKTQGAVARMQEDRDGSCSTVGGVGYGDSKDCILEPLSLPESPGGTTTLEGSPSVPCIFCEEHFPVAEQDKL
  LKHMIIEHKIVIADVKLVADFQRYILYWRKRFTEQPITDFCSVIRINSTAPFEEQENYFLLCDVLPEDRILREEL
  QKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKLDNLQ
  CLYCEKTFRDKNTLKDHMRKKQHRKINPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPA
  SAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTH
  MEETKHTSLLPDRKTWDQLEYYFPTYENDTLLCTLSDSESDLTAQEQNENVPIISEDTSKLYALKQSSILNQLLL

• Structural information:
  • Interpro: IPR041661  IPR040048  IPR036236  IPR013087  
  • Prosite: PS00028 PS50157
  • STRING: ENSP00000354501
• Other Databases: GeneCards:  ZNF277  Malacards:  ZNF277

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046872	metal ion binding	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA	molecular function
GO:0070301	cellular response to hydrogen peroxide	IEA	biological process
GO:2000772	regulation of cellular senescence	IEA	biological process
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq