• Gene id: 1101

Gene Summary

• Gene Symbol: CHAD   Gene   UCSC   Ensembl
• Aliases: SLRR4A
• Gene name: chondroadherin
• Alternate names: chondroadherin, cartilage leucine-rich protein, chondroadherin proteoglycan,
• Gene location: 17q21.33 (50469880: 50464491)     Exons: 4     NC_000017.11
• Gene summary(Entrez): Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [pr
• OMIM: 602178

Protein Summary

• Protein general information: O15335  
  • Name: Chondroadherin (Cartilage leucine rich protein)
  • Length: 359  
  • Mass: 40476
  • Tissue specificity: Present in chondrocytes at all ages.
• Sequence:

  MVRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMP
  NLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLF
  ILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELK
  LSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNN
  PWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFRSCKFPTKRSKKAGRH

• Structural information:
  • Protein Domains: (23..5-)
    (/note="LRRNT-)
    (300..34-)
    (/note="LRRCT"-)
  • Interpro: IPR000483  IPR001611  IPR003591  IPR032675  IPR000372  
  • Prosite: PS51450
  • PDB: 5LFN 5MX1
  • PDBsum: 5LFN 5MX1
  • STRING: ENSP00000423812
• Other Databases: GeneCards:  CHAD  Malacards:  CHAD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0031012	extracellular matrix	IBA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:1900155	negative regulation of bone trabecula formation	IEA	biological process
GO:0060348	bone development	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq