• Gene id: 10903

Gene Summary

• Gene Symbol: MTMR11   Gene   UCSC   Ensembl
• Aliases: CRA
• Gene name: myotubularin related protein 11
• Alternate names: myotubularin-related protein 11, cisplatin resistance associated, cisplatin resistance-associated protein, hCRA, inactive phosphatidylinositol 3-phosphatase 11,
• Gene location: 1q21.2 (149938328: 149928650)     Exons: 8     NC_000001.11

Protein Summary

• Protein general information: A4FU01  
  • Name: Myotubularin related protein 11 (Cisplatin resistance associated protein) (hCRA) (Inactive phosphatidylinositol 3 phosphatase 11)
  • Length: 709  
  • Mass: 79545
  • Tissue specificity: Expressed in bone marrow, spleen and thymus. {ECO
• Sequence:

  MWWGGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAWAPGVRKGLEPELSGTLICTNF
  RVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGL
  EPQAFQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNERFDV
  ATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDV
  VLVDTMDELPSLADVQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQE
  RGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEEAPVFLLFLDCVWQLLQQFPA
  DFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNA
  QILQFQNPGYDPEHCPDSWLPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSE
  SLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHLQELLRKWTPR
  ISPEDHSKKRDPHTILNPTEIAGILKGRAEGDLG

• Structural information:
  • Protein Domains: (196..63-)
    (/note="Myotubularin-phosphatase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00669"-)
  • Interpro: IPR030580  IPR022587  IPR010569  IPR030564  IPR029021  
  • Prosite: PS51339
  • STRING: ENSP00000391668
• Other Databases: GeneCards:  MTMR11  Malacards:  MTMR11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046856	phosphatidylinositol dephosphorylation	IBA	biological process
GO:0004438	phosphatidylinositol-3-phosphatase activity	IBA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)