• Gene id: 10733

Gene Summary

• Gene Symbol: PLK4   Gene   UCSC   Ensembl
• Aliases: MCCRP2, SAK, STK18
• Gene name: polo like kinase 4
• Alternate names: serine/threonine-protein kinase PLK4, Snk akin kinase, serine/threonine-protein kinase 18, serine/threonine-protein kinase Sak,
• Gene location: 4q28.1 (127880892: 127899223)     Exons: 17     NC_000012.12
• Gene summary(Entrez): This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternative
• OMIM: 605031

KEGG pathways

Pathway id	Pathway name
hsa04068	FoxO signaling pathway
hsa04068	FoxO signaling pathway

Diseases

Associated diseases	References
Cancer (breast)	GAD: 20508983
Chronic renal failure	GAD: 21085059
Non obstructive azoospermia	MIK: 26452337
Sertoli cell only syndrome (SCOS)	MIK: 26452337
Autosomal recessive microcephaly and chorioretinopathy	GAD: H01880
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Sertoli cell-only syndrome (SCOS)	MIK: 26452337
Non obstructive azoospermia	MIK: 26452337
Male infertility	MIK: 26452337
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
26452337	Sertoli cell-only syndrome (SCOS), Non obstructive azoospermia, Male infertility			81 patients with azoospermia and Sertoli cell-only syndrome (SCOS)	Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R