• Gene id: 10714

Gene Summary

• Gene Symbol: POLD3   Gene   UCSC   Ensembl
• Aliases: P66, P68, PPP1R128
• Gene name: DNA polymerase delta 3, accessory subunit
• Alternate names: DNA polymerase delta subunit 3, DNA polymerase delta subunit C, DNA polymerase delta subunit p66, DNA polymerase delta subunit p68, Pol delta C subunit (p66), polymerase (DNA) delta 3, accessory subunit, polymerase (DNA-directed), delta 3, accessory subunit, pro,
• Gene location: 11q13.4 (74592529: 74669340)     Exons: 14     NC_000077.6
• Gene summary(Entrez): This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the acti
• OMIM: 611415

KEGG pathways

Pathway id	Pathway name
hsa03440	Homologous recombination
hsa03420	Nucleotide excision repair
hsa03030	DNA replication
hsa03430	Mismatch repair
hsa03410	Base excision repair

Diseases

Associated diseases	References
Cancer (bladder)	GAD: 19237606
Associated in human sperm interaction with homologous zona pellucida	MIK: 12801567
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Associated in human sperm interaction with homologous zona pellucida	MIK: 12801567
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
12801567	Associated in human sperm interaction with homologous zona pellucida				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray