• Gene id: 10561

Gene Summary

• Gene Symbol: IFI44   Gene   UCSC   Ensembl
• Aliases: MTAP44, TLDC5, p44
• Gene name: interferon induced protein 44
• Alternate names: interferon-induced protein 44, TBC/LysM-associated domain containing 5, interferon-induced, hepatitis C-associated microtubular aggregate protein (44kD), microtubule-associated protein 44,
• Gene location: 1p31.1 (78648942: 78664077)     Exons: 10     NC_000001.11
• OMIM: 610468

Protein Summary

• Protein general information: Q8TCB0  
  • Name: Interferon induced protein 44 (p44) (Microtubule associated protein 44)
  • Length: 444  
  • Mass: 50491
• Sequence:

  MAVTTRLTWLHEKILQNHFGGKRLSLLYKGSVHGFRNGVLLDRCCNQGPTLTVIYSEDHIIGAYAEESYQEGKYA
  SIILFALQDTKISEWKLGLCTPETLFCCDVTKYNSPTNFQIDGRNRKVIMDLKTMENLGLAQNCTISIQDYEVFR
  CEDSLDERKIKGVIELRKSLLSALRTYEPYGSLVQQIRILLLGPIGAGKSSFFNSVRSVFQGHVTHQALVGTNTT
  GISEKYRTYSIRDGKDGKYLPFILCDSLGLSEKEGGLCRDDIFYILNGNIRDRYQFNPMESIKLNHHDYIDSPSL
  KDRIHCVAFVFDASSIQYFSSQMIVKIKRIRRELVNAGVVHVALLTHVDSMDLITKGDLIEIERCEPVRSKLEEV
  QRKLGFALSDISVVSNYSSEWELDPVKDVLILSALRRMLWAADDFLEDLPFEQIGNLREEIINCAQGKK

• Structural information:
  • Protein Domains: (1..15-)
    (/note="TLDc-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01234"-)
  • Interpro: IPR024644  IPR027417  IPR006571  
  • Prosite: PS51886
  • STRING: ENSP00000359783
• Other Databases: GeneCards:  IFI44  Malacards:  IFI44

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006955	immune response	IBA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0009615	response to virus	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0009617	response to bacterium	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R