• Gene id: 10388

Gene Summary

• Gene Symbol: SYCP2   Gene   UCSC   Ensembl
• Aliases: SCP-2, SCP2, SPGF1
• Gene name: synaptonemal complex protein 2
• Alternate names: synaptonemal complex protein 2, synaptonemal complex lateral element protein,
• Gene location: 20q13.33 (59933699: 59863276)     Exons: 47     NC_000020.11
• Gene summary(Entrez): The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The
• OMIM: 606456

Protein Summary

• Protein general information: Q9BX26  
  • Name: Synaptonemal complex protein 2 (SCP 2) (Synaptonemal complex lateral element protein) (hsSCP2)
  • Length: 1530  
  • Mass: 175639
• Sequence:

  MPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHNVSAILVSVGR
  CGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVES
  FVPRICSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCR
  MTTEKQRQELAHQWFSMDFIAKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEK
  LEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPEEKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFD
  ASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPESQISPVGEELVSLKEKSKSPKEFAKP
  SKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQMTSSAEKPSV
  SQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILP
  GVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKE
  QTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVN
  TATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLK
  ESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACAD
  RSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNH
  KSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVK
  EENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKD
  FTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRK
  KISSLVLTQETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATH
  VSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQ
  NEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENF
  EKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDR
  LLKDMLEEELLNVRRELMSVFMSHERNANV

• Structural information:
  • Interpro: IPR024835  IPR024832  IPR041322  IPR040560  
  • STRING: ENSP00000350162
• Other Databases: GeneCards:  SYCP2  Malacards:  SYCP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0140013	meiotic nuclear division	IBA	biological process
GO:0007143	female meiotic nuclear division	IBA	biological process
GO:0007140	male meiotic nuclear division	IBA	biological process
GO:0000800	lateral element	IBA	cellular component
GO:0000780	condensed nuclear chromosome, centromeric region	IBA	cellular component
GO:0000800	lateral element	ISS	cellular component
GO:0051301	cell division	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000795	synaptonemal complex	IEA	cellular component
GO:0000800	lateral element	IEA	cellular component
GO:0000795	synaptonemal complex	IEA	cellular component
GO:0000800	lateral element	IEA	cellular component
GO:0007140	male meiotic nuclear division	IEA	biological process
GO:0007143	female meiotic nuclear division	IEA	biological process
GO:0009566	fertilization	IEA	biological process
GO:0009887	animal organ morphogenesis	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0048808	male genitalia morphogenesis	IEA	biological process
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000795	synaptonemal complex	NAS	cellular component
GO:0007130	synaptonemal complex assembly	NAS	biological process
GO:0005634	nucleus	NAS	cellular component
GO:0003677	DNA binding	NAS	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray