• Gene id: 10272

Gene Summary

• Gene Symbol: FSTL3   Gene   UCSC   Ensembl
• Aliases: FLRG, FSRP
• Gene name: follistatin like 3
• Alternate names: follistatin-related protein 3, follistatin-like 3 (secreted glycoprotein), follistatin-like protein 3, follistatin-related gene protein,
• Gene location: 19p13.3 (676391: 683384)     Exons: 5     NC_000019.10
• Gene summary(Entrez): Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
• OMIM: 605343

SNPs

rs4919686

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000010.11   g.102832492A>C
NC_000010.10   g.104592249A>C
NG_007955.1   g.10042T>G|SEQ=[A/C]|GENE=CYP17A1
CYP17A1-AS1   102724307

Protein Summary

• Protein general information: O95633  
  • Name: Follistatin related protein 3 (Follistatin like protein 3) (Follistatin related gene protein)
  • Length: 263  
  • Mass: 27663
  • Tissue specificity: Expressed in a wide range of tissues. {ECO
• Sequence:

  MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLT
  HPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRA
  ARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMR
  QATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV

• Structural information:
  • Protein Domains: (36..10-)
    (/note="TB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00697-)
    (99..11-)
    (/note="Follistatin-like-1)
    (113..16-)
    (/note="Kazal-like-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798-)
    (170..19-)
    (/note="Follistatin-li-)
  • Interpro: IPR003645  IPR015369  IPR002350  IPR036058  IPR017878   IPR036773  
  • Prosite: PS51465 PS51364
  • PDB: 2KCX 3B4V 3SEK
  • PDBsum: 2KCX 3B4V 3SEK
  • STRING: ENSP00000166139
• Other Databases: GeneCards:  FSTL3  Malacards:  FSTL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0030154	cell differentiation	IBA	biological process
GO:0030510	regulation of BMP signaling pathway	IBA	biological process
GO:0032926	negative regulation of activin receptor signaling pathway	IBA	biological process
GO:0007275	multicellular organism development	IBA	biological process
GO:0048185	activin binding	IBA	molecular function
GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	IDA	biological process
GO:0006357	regulation of transcription by RNA polymerase II	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	biological process
GO:0030514	negative regulation of BMP signaling pathway	IDA	biological process
GO:0022409	positive regulation of cell-cell adhesion	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0048185	activin binding	IPI	molecular function
GO:0048185	activin binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001968	fibronectin binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0001503	ossification	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0044267	cellular protein metabolic process	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0043687	post-translational protein modification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0030325	adrenal gland development	IEA	biological process
GO:0030141	secretory granule	IEA	cellular component
GO:0007283	spermatogenesis	IEA	biological process
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0001822	kidney development	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0071248	cellular response to metal ion	IEA	biological process
GO:0044306	neuron projection terminus	IEA	cellular component
GO:0030324	lung development	IEA	biological process
GO:0008584	male gonad development	IEA	biological process
GO:0048185	activin binding	IEA	molecular function
GO:0030514	negative regulation of BMP signaling pathway	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0045671	negative regulation of osteoclast differentiation	IDA	biological process
GO:0032926	negative regulation of activin receptor signaling pathway	IDA	biological process
GO:0032926	negative regulation of activin receptor signaling pathway	IDA	biological process
GO:0002244	hematopoietic progenitor cell differentiation	IDA	biological process
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R