• Gene id: 100130958

Gene Summary

• Gene Symbol: SYCE1L   Gene   UCSC   Ensembl
• Aliases: MRP2
• Gene name: synaptonemal complex central element protein 1 like
• Alternate names: synaptonemal complex central element protein 1-like, meiosis-related protein,
• Gene location: 16q23.1 (77199407: 77213214)     Exons: 11     NC_000016.10

Protein Summary

• Protein general information: A8MT33  
  • Name: Synaptonemal complex central element protein 1 like (Meiosis related protein)
  • Length: 242  
  • Mass: 27397
• Sequence:

  MAGKLKPLNVEAPEATEEAEGQAKSLKTEDLLAMVIKLQKEGSLEPQIEDLISRINDLQQAKKKSSEELRETHSL
  WEALHRELDSLNGEKVHLEEVLGKKQEALRILQMHCQEKESEAQRLDVRGQLEDLMGQHKDLWEFHMLEQRLARE
  IRALERSKEQLLSERRLVRAKLREVERRLHSPPEVEGAMAVNDGLKAELEIFGEQVRSAPEVGAGEGEAGPELPR
  ARDEEDPEPPVAAPDAL

• Structural information:
  • Interpro: IPR026676  
  • STRING: ENSP00000367911
• Other Databases: GeneCards:  SYCE1L  Malacards:  SYCE1L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000795	synaptonemal complex	IBA	cellular component
GO:0000795	synaptonemal complex	IEA	cellular component
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0070193	synaptonemal complex organization	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0045111	intermediate filament cytoskeleton	IDA	cellular component

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 31479588
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31479588	Non obstructive azoospermia	c.22C>G p.(Leu8Val)	Brazil, South America n	18 non-obstructive azoospermia	Male infertility	NGS
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)