• Gene id: 1001

Gene Summary

• Gene Symbol: CDH3   Gene   UCSC   Ensembl
• Aliases: CDHP, HJMD, PCAD
• Gene name: cadherin 3
• Alternate names: cadherin-3, cadherin 3, type 1, P-cadherin (placental), calcium-dependent adhesion protein, placental,
• Gene location: 16q22.1 (68644913: 68727572)     Exons: 18     NC_000016.10
• Gene summary(Entrez): This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This cal
• OMIM: 142703

Protein Summary

• Protein general information: P22223  
  • Name: Cadherin 3 (Placental cadherin) (P cadherin)
  • Length: 829  
  • Mass: 91418
  • Tissue specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines. {ECO
• Sequence:

  MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTV
  RNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGA
  DSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVL
  EGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQA
  TDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGD
  HFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQ
  EGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGS
  PPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGD
  TVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLL
  LVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPAN
  PDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGG
  GEDD

• Structural information:
  • Protein Domains: (108..21-)
    (/note="Cadherin-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00043-)
    (216..32-)
    (/note="Cadherin-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00043-)
    (329..44-)
    (/note="Cadherin-3)
    (/evidence="ECO:0000255|PROSITE-ProRule-)
  • Interpro: IPR039808  IPR002126  IPR015919  IPR020894  IPR000233   IPR014868  IPR027397  
  • Prosite: PS00232 PS50268
  • PDB: 4OY9 4ZML 4ZMN 4ZMO 4ZMP 4ZMQ 4ZMT 4ZMV 4ZMW 4ZMX 4ZMY 4ZMZ 5JYL 5JYM
  • PDBsum: 4OY9 4ZML 4ZMN 4ZMO 4ZMP 4ZMQ 4ZMT 4ZMV 4ZMW 4ZMX 4ZMY 4ZMZ 5JYL 5JYM
  • STRING: ENSP00000264012
• Other Databases: GeneCards:  CDH3  Malacards:  CDH3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0007043	cell-cell junction assembly	IBA	biological process
GO:0007275	multicellular organism development	IBA	biological process
GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	biological process
GO:0016342	catenin complex	IBA	cellular component
GO:0000902	cell morphogenesis	IBA	biological process
GO:0005509	calcium ion binding	IBA	molecular function
GO:0005912	adherens junction	IBA	cellular component
GO:0034332	adherens junction organization	IBA	biological process
GO:0044331	cell-cell adhesion mediated by cadherin	IBA	biological process
GO:0045296	cadherin binding	IBA	molecular function
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	IBA	biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0098609	cell-cell adhesion	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0007601	visual perception	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0050896	response to stimulus	IEA	biological process
GO:0007155	cell adhesion	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007155	cell adhesion	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0034332	adherens junction organization	TAS	biological process
GO:0042060	wound healing	IEA	biological process
GO:0098609	cell-cell adhesion	IEA	biological process
GO:0005912	adherens junction	IEA	cellular component
GO:0042493	response to drug	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0030054	cell junction	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0001895	retina homeostasis	IMP	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP	biological process
GO:0051796	negative regulation of timing of catagen	IMP	biological process
GO:0032912	negative regulation of transforming growth factor beta2 production	IMP	biological process
GO:0022405	hair cycle process	IMP	biological process
GO:0010838	positive regulation of keratinocyte proliferation	IMP	biological process
GO:0060901	regulation of hair cycle by canonical Wnt signaling pathway	IMP	biological process
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	IMP	biological process
GO:0032773	positive regulation of monophenol monooxygenase activity	IMP	biological process
GO:0031424	keratinization	IMP	biological process
GO:0003674	molecular_function	ND	molecular function
GO:1902910	positive regulation of melanosome transport	IMP	biological process
GO:0048023	positive regulation of melanin biosynthetic process	IMP	biological process
GO:0010628	positive regulation of gene expression	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04514	Cell adhesion molecules

Diseases

Associated diseases	References
Ectodermal dysplasia, ectrodactyly, and macular dystrophy	KEGG:H00639
Congenital hypotrichosis with juvenile macular dystrophy	KEGG:H00785
Ectodermal dysplasia, ectrodactyly, and macular dystrophy	KEGG:H00639
Congenital hypotrichosis with juvenile macular dystrophy	KEGG:H00785
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881